From St. Charles, MO (I-270): Take exit 3B to merge onto IL-3 N/Lewis & Clark Blvd. heading towards Alton. Continue on IL-3 N/Lewis & Clark Blvd. Turn left at Piasa Lane. Turn left at Confluence Tower Dr.

From Downtown St. Louis (I-70): Take exit 248A toward Salisbury St. Take McKinnely Bridge entering Illinois. Continue onto Cedar St. Continue on IL-3 N/Lewis & Clark Blvd. Turn left at Piasa Lane. Turn left at Confluence Tower Dr.

From Downtown St. Louis (I-55 N): Take I-55 North to I-255. Take I-255 North to the New Poag Rd exit. Turn left(west) off the New Poag Rd. exit and continue about 3 miles. Turn right on IL-3 N/Lewis & Clark Blvd. Turn left at Piasa Lane. Turn left at Confluence Tower Dr.

From Springfield, IL (I-55 S): Take exit 20B to merge onto I-270 W. Take exit 3B to merge onto IL-3 N/Lewis & Clark Blvd. heading towards Alton. Continue on IL IL-3 N/Lewis & Clark Blvd. Turn left at Piasa Lane. Turn left at Confluence Tower Dr.

From Florissant, MO (MO-367): Take MO 367 N/Lewis & Clark Blvd. Continue onto US-67 N. Turn right at IL-143 E. Turn right on IL-3/Lewis & Clark Blvd. Turn right at Piasa Lane. Turn left at Confluence Tower Dr.